PRINCIPLES OF ORGANIC CHEMISTRY

The aims of this course is to transmit to the student a good and solid grounding in the basic principles of organic chemistry through study of the structure-function relationships of organic compounds, the chemistry of functional groups, and reactions of organic compounds, which are required for the successful completion of other courses of general background, such as pharmaceutical chemistry, pharmacology and biochemistry

Upon successful completion of this course, students will be able to know the structure and nomenclature of the principal functional groups of organic compounds, their chemistry and reactivity.

At the end of the course the students will:

1. Know and recall the fundamental principles of organic chemistry that include chemical bonding, nomenclature, structural isomerism, stereochemistry, chemical reactions and mechanism.
2. Name the functional groups and different class of organic compounds.
3. Recognize the basic practical skills for the synthesis and analysis of organic compounds.
4. Predict the reactivity of an organic compound from its structure.
5. Develop basic skills for the multi-step synthesis of organic compounds.
6. Justify a reasonable mechanism for a chemical reaction.

The lectures for this course will be a combination of classic blackboard lectures and PowerPoint.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes, in line with the planned programme .

In case of students with disabilities and/or SLD, in accordance with the Italian Law (170/2010), it is possible to adapt assessment and study methods, without modifying learning objectives; this support includes dispensatory measures and compensatory tools. To request the service, the student must inform professor at the beginning of the course or at least 30 days before the exam.

Furthermore, it is possible to contact Prof. Teresa Musumenci, CInAP (Centro per l’Integrazione Attiva e Partecipata - Servizi per le Disabilità e/o DSA) referent teacher of our Department.

PART 1. Introduction to Organic Chemistry

1. Structure and Bonding
2. Acids and Bases
3. Introduction to Organic Molecules and Functional Groups
4. Alkanes

PART 2. Stereochemistry, organic reactions and delocalization

1. Stereochemistry
2. Understanding Organic Reactions
3. Alkyl Halides and Nucleophilic Substitution
4. Alkyl Halides and Elimination Reactions
5. Alcohols, Ethers, and Related Compounds
6. Alkenes
7. Alkynes
8. Oxidation and Reduction
9. Radical Reactions
10. Conjugation, Resonance, and Dienes

PART 3. Aromatic Compounds

1. Benzene and Aromatic Compounds
2. Reactions of Aromatic Compounds

PART 4. Carbonyl compounds and amines

1. Carbonyl Chemistry: Aldehydes and Ketones
2. Carboxylic Acids, Their Derivatives and Nitriles
3. Carbonyl Condensation Reactions
4. Amines

PART 5. Bioorganic compounds

1. Lipids
2. Carbohydrates
3. Amino Acids and Proteins
4. Nucleic acids

1. Fondamenti di Chimica Organica – J. C. Smith – 3^a Ed. 2018 – McGraw-Hill, ISBN 978-88-386-9443-1
2. Fondamenti di Chimica Organica – L. G. Wade – 1ª Ed. 2015 – Piccin, ISBN 978-88-299-2300-7
3. Chimica Organica – P. Y. Bruice – 2^a Ed. 2017 – EdiSES, ISBN 978-88-795-9935-1
4. Esercizi risolti di Chimica Organica – N. E. Schore e K. P. C. Vollhardt – 4^a Ed. 2016 – Zanichelli, ISBN 9788808436900