IDENTIFICATION OF DRUGS A - L

At the end of the course, which also consists of laboratory exercises in a single place, the student acquires the knowledge and practice for the identification of compounds of pharmaceutical interest, mainly with organic structure, by means of specific chemical assays and instrumental analytical techniques. The student will be able to employ the methods reported in the Italian Official Pharmacopoeia and European Pharmacopoeia.

Preliminary testing: Tasting notes, essays Combustion, organic elemental analysis, quantitative elemental analysis, examination of the chemical, solubility assays

Physical Constants: Melting Point, Boiling Point, Density, Refractive index,

Polarimetry (specific rotatory power: determination of specific rotatory power; scheme of the instrument, determination of optical purity).

Recognition of Functional Groups:

Carboxylic acids, hydroxy acids, phenols, alcohols, aldehydes and ketones, esters, anhydrides, ethers, halogen derivatives, amines, amides, amino acids, nitro compounds, hydrocarbons.

IR spectroscopy

Spectroscopy molecular absorption: General

Classical model, quantum model, frequency group, polyatomic molecules

Interpretation of the IR spectrum

Instrumentation

Sample preparation and recording of the spectrum

applications

MASS spectrometry

the instrumentation

Ionization techniques

Analysis of fragmentation in EI

analyzers

Tandem mass spectrometry

Applications of mass spectrometry

Monographs: benzoic acid, ascorbic acid, tartaric acid, methyl and propyl p-hydroxybenzoate, acetylsalicylic acid, benzocaine, adrenaline, saccharin, paracetamol.

DEFINITION OF ANALYTICAL PROFILES OF THE FOLLOWING CLASSES OF DRUGS

-Sulfonamides: a) Antibiotics b) Antidiabetic agents c) Diuretics

-Carbohydrates: glucose, fructose, lactose, sucrose

-Benzodiazepine

-Steroids

-Beta-lactam antibiotics

- CAVRINI-ANDRISANO "Analisi Farmaceutica" vecchia (2004) e nuova (2009) edizione

- SAVELLI-BRUNO “Analisi chimico farmaceutica” Piccin (ristampa 2005);

- CARTA-MAMOLO-NOVELLI-PIRAS “Analisi Farmaceutica Qualitativa”

EdiSES (2011)