PHARMACOLOGY AND PHARMACOTHERAPY

Objective of the course to provide the pharmacological basis useful for understanding the therapeutic use of single classes of drugs on the basis of their mechanism of action and the principles of pharmacokinetics

At the end of the course, to pass the exam, the student must demonstrate that he has acquired the knowledge related to:

• general pharmacokinetic concepts;
• general concepts of pharmacodynamics;
• mechanism of action, pharmacokinetic profile, therapeutic indications and side effects of the drugs indicated in the program

Face-to-face lectures

General Pharmacology

Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination.

Pharmacokinetic parameters. Bioavailability, Volume of distribution, Clearance, half-life.

Pharmacodynamics: Classification of receptors and signal transduction mechanisms. Pharmacology of ion channels.

Drug-receptor interaction. Dose-response curves: Agonists, partial agonists, inverse agonists and antagonists. Potency and efficacy of drugs.

Pharmacogenetics and Pharmacogenomics. Tolerance. Side effects, idiosyncratic and allergic effects. teratogenicity

Drug Interactions

Systematic pharmacology

Catecholaminergic neurotransmission. Sympathomimetic and sympatholytic drugs

Cholinergic neurotransmission. Parasympathomimetic drugs. Parasympatholytic drugs.

Pharmacology of neuromuscular transmission

GABAergic neurotransmission. Drugs active on GABAergic transmission.

Glutamatergic neurotransmission

Pharmacology of cardiovascular function

-Pharmacotherapy of Hypertension

-Pharmacotherapy of Congestive Heart Failure

-Angina treatment drugs

-Anti-Arrhythmic Drugs

Drugs affecting renal system

-diuretics

Respiratory system drugs

- Antitussive drugs

- Bronchodilator drugs

Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, Laxatives and antidiarrheal drugs

Pharmacology of inflammatory and allergic processes

-Autacoids and mediators of inflammation

- Antihistamin drugs

- Non-steroidal anti-inflammatory drugs

Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus

Drug Therapy for Hypercholesterolemia and Dyslipidemia

Drugs Therapy for bone metabolism

Endocrine system pharmacology

- Thyroid hormones and antithyroid drugs

- Estrogens, androgens, progestogens

Drugs for erectile dysfunction

Central Nervous System Pharmacology

-Drug therapy of Anxiety Disorders

-Hypnotics and Sedatives

-Pain Management

-Drug Therapy of Depression

-Pharmacotherapy of Psychosis

-Treatment of Parkinson Disease

-Pharmacotherapy of the Epilepsies

-General Anesthetics. Local Anesthetics

Textbook information

F. Rossi, V. Cuomo, C. Riccardi-Farmacologia, Edizioni Minerva Medica

L.Annunziato, G. Di Rienzo-Trattato di farmacologia, Idelson-Gnocchi

Katzung BG- Farmacologia Generale e Clinica, Piccin

Testo di approfondimento:

Goodman and Gilman. Le basi farmacologiche della terapia. Ultima edizione. Zanichelli