CHIMICA ORGANICA

The aims of this course is to transmit to the student a good and solid grounding in the basic principles of organic chemistry through study of the structure-function relationships of organic compounds, the chemistry of functional groups, and reactions of organic compounds, which are required for the successful completion of other courses of general background, such as pharmaceutical chemistry, pharmacology and biochemistry

Upon successful completion of this course, students will be able to know the structure and nomenclature of the principal functional groups of organic compounds, their chemistry and reactivity.

At the end of the course the students will:

1. Know and recall the fundamental principles of organic chemistry that include chemical bonding, nomenclature, structural isomerism, stereochemistry, chemical reactions and mechanism.
2. Name the functional groups and different class of organic compounds.
3. Recognize the basic practical skills for the synthesis and analysis of organic compounds.
4. Predict the reactivity of an organic compound from its structure.
5. Develop basic skills for the multi-step synthesis of organic compounds.
6. Justify a reasonable mechanism for a chemical reaction.

The teaching is given as lectures and exercises

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes, in line with the planned programme .

In case of students with disabilities and/or SLD, in accordance with the Italian Law (170/2010), it is possible to adapt assessment and study methods, without modifying learning objectives; this support includes dispensatory measures and compensatory tools. To request the service, the student must inform professor at the beginning of the course or at least 30 days before the exam.

Furthermore, it is possible to contact Prof. Teresa Musumenci, CInAP (Centro per l’Integrazione Attiva e Partecipata - Servizi per le Disabilità e/o DSA) referent teacher of our Department.

PART ONE: An Introduction to the Study of Organic Chemistry

1. Remembering General Chemistry: Electronic Structure and Bonding

2. Acids and Bases: Central to Understanding Organic Chemistry

3. An Introduction to Organic Compounds: Nomenclature, Physical Properties, and Structure

PART TWO: Electrophilic Addition Reactions, Stereochemistry, and Electron Delocalization

4. Isomers: The Arrangement of Atoms in Space

5. Alkenes: Structure, Nomenclature, and an Introduction to Reactivity • Thermodynamics and Kinetics

6. The Reactions of Alkenes • The Stereochemistry of Addition Reactions

7. The Reactions of Alkynes • An Introduction to Multistep Synthesis

8. Delocalized Electrons: Their Effect on Stability, pKa, and the Products of a Reaction • Aromaticity and Electronic Effects: An Introduction the Reactions of Benzene

PART THREE: Substitution and Elimination Reactions

9. Substitution and Elimination Reactions of Alkyl Halides

10. Reactions of Alcohols, Ethers, Epoxides, Amines, and Sulfur-Containing Compounds

11. Organometallic Compounds

12. Radicals

PART FOUR: Carbonyl Compounds

15. Reactions of Carboxylic Acids and Carboxylic Acid Derivatives

16. Reactions of Aldehydes and Ketones • More Reactions of Carboxylic Acid Derivatives

17. Reactions at the α-Carbon

PART FIVE: Aromatic Compounds

18. Reactions of Benzene And Substituted Benzenes

19. Reactions of Amines

19/1. The chemistry of Heteroaromatic Compounds

PART SIX: Bioorganic Compounds

20. The Organic Chemistry Of Carbohydrates

21. Amino Acids, Peptides, and Proteins

22. Catalysis in Organic Reactions and in Enzymatic Reactions

25. The Chemistry of Lipids

26. The Chemistry of the Nucleic Acids

1. Chimica Organica – P. Y. Bruice – 3^a Ed. 2017 – EdiSES, ISBN 9788879599351 (with a molecular model kit).
2. Chimica Organica – AA. VV. a cura di B. Botta, – 2ª Ed. 2016 – Edi-Ermes, ISBN 9788870514780
3. Chimica Organica – P. C. Vollhardt, N. E. Schore, – 4ª Ed. 2016 – Zanichelli, ISBN 9788808721235
4. Esercizi risolti di Chimica Organica – N. E. Schore e K. P. C. Vollhardt – 4^a Ed. 2016 – Zanichelli, ISBN 9788808436900