TECNOLOGIA FARMACEUTICA CON LABORATORIO A - L

The course aims to deepen technological, biopharmaceutical and formulative aspects of both traditional and innovative pharmaceutical formulation, now available to the medical therapy.

In particular, it will be pay great attention to the fields of interest concerning the preparation of both magistral and officinal galenic medicines, and controls assay provided by the NBP (Guidelines of good preparation) and the Pharmacopoeia in force.

PART 1 (5 CFU)

SECTION 1A

Stability and biopharmaceutic (1 CFU)

Stability and stabilization of medicinal

Rules for the proper preservation, preservatives (antimicrobials and antioxidants), general characteristics of the containers for medicines.

Concepts of biopharmaceutic

Influence of selected formulation on the bioavailability and activity of drugs. Preformulation.

Conventional pharmaceutical preparations (4 CFU)

Water for pharmaceutical use; aqueous and hydroalcoholic solutions in pharmacy; suspensions, emulsions, surfactants.

Liquid preparations for oral use (syrups, powders and granules for syrups, solutions, emulsions, suspensions, powders for solutions or suspensions, drops, powders drops).

Ophthalmic preparations (eye drops, eye baths, powders for eye drops and eye baths, ophthalmic semisolid preparations, ocular inserts).

Parenteral preparations: classification, routes of administration, requirements, chemico-physical and biological assays.

Pressurized pharmaceutical forms.

The solid dosage forms: classification, routes of administration, requirements, chemico-physical and biological assays of powders, granules, tablets and capsules. Coating of tablets: pelleting, filming, enteric coatings.

Semi-solid and topical pharmaceutical forms.

Semi-solid preparations for cutaneous application (ointments, creams, gels, pastes, poultices, medicated plasters).

Rectal preparations (suppositories).

Vaginal preparations (ovules)

Nasal and headsets preparations.

PART 2 (4 CFU)

Unconventional and innovative pharmaceutical preparations (3 CFU)

Pharmaceutical preparations to achieve modified release

Oral forms, trans-mucosal, ophthalmic, subcutaneous grafting plants, transdermal systems.

Drug Delivery System (DDS) for drug release

Vesicular systems (liposomes, niosomes). Micro and nanoparticulate polymeric systems. Lipidic nanoparticulate systems (SLN and NLC).

Chemical approach for the improvement of drug physico-chemical properties

Prodrugs and polymeric prodrugs, drug-polymer conjugates, molecular inclusion systems (cyclodextrins).

Complementary fields of pharmaceutical interest (1 CFU)

Traditional and modern herbal preparations.

Outline of the theoretical fundamentals and the technology of homeopathic preparations.

LABORATORY OF PHARMACEUTICAL GALENIC (5 CFU)

Fundamental pharmaceutical operations

Basic operations in pharmaceutical technology

Solution, filtration, concentration, drying, freeze drying, sterilization, grinding and pulverizing, granulating.

Definition and development of medicines. Galenic and industrial medicines. Official Italian Pharmacopoeia (F.U.I.) XII edition. European Pharmacopoeia VIII Edition. Guidelines of good preparation (N.B.P.).

The magistral preparation (exercises to individual place)

Exam concerning the delivery of prescriptions. Incompatibility. Rate National of Medicines. Techniques for the preparation of the most common galenic pharmaceutical forms.

Lessons will be supplemented by group seminars.

SUGGESTED BOOKS FOR STUDY
1. P. Colombo et al. - PRINCIPI DI TECNOLOGIA FARMACEUTICA – seconda
edizione – Casa Editrice Ambrosiana, 2015.
2. M. Amorosa – PRINCIPI DI TECNICA FARMACEUTICA - Libr. Univ. Tinarelli,
Bologna 1998.
3. M.E. Aulton – TECNOLOGIE FARMACEUTICHE Progettazione e allestimento dei
medicinali. Edizioni EDRA, 2013.
4. Medicamenta VII Ed. (1° vol.) - Cooperativa Farmaceutica, Milano.
5. Enrico Ragazzi “Galenica Pratica” Formulazione e Tecnologia. – Ed. 2006 – Libreria
Internazionale Cortina Padova.
6. Franco Bettiol - Manuale delle preparazioni galeniche Tecniche Nuove Ed. 2003.

BOOKS TO BE CONSULTED
7. F.U.I. XII Ed. and supplements.
8. Farmacopea Europea VIII Ed. and supplements.
9. T.A. Florence & D. Attwood – Le basi chimico-fisiche della tecnologia farmaceutica -
McMillan Press 2002.
10. Martin - Physical Pharmacy - Lea & Febiger, Philadelphia, London.
11. Remington’s Pharmaceutical Sciences, 19th Ed.
12. Livingstone – Pharmaceutics. The science of dosage form design- Ed. ME Aulton.
13. Teacher's online slides.