LABORATORIO DI BIOTECNOLOGIE FARMACEUTICHE E DI PREPARAZIONE ESTRATTIVA E SINTETICA DEI FARMACI

To provide the basic Biotechnological and Pharmaceutical knowhow used in Medicinal Chemistry

MODULE A (Prof. A. Marrazzo) - (6 CFU)

biotechnological and biomolecular methods for drug design and production. Manipulation of genic expression and production of recombinant protein in prokaryotic and eukaryotic cells. Downstream processing of protein products. Therapeutic proteins. Citokines. Vaccines. Monoclonal antibodies. Oligonucleotides (ON): ON-medicinal Chemistry, pharmacokinetics and toxicology. Antisense technology, aptamers, decoy, anti-genes, ribozymes, RNA-interference, micro-RNA. Bioinformatics.

MODULO B (Prof.ssa L. Pasquinucci) - (3 CFU)

The disconnection approach. Synthesis of aromatic compounds. One-group C-X and C-C disconnections. Two-group C-X disconnections: 1,3-difunctionalised, 1,5-difunctionalised, 1,4-difunctionalised and 1,6-difunctionalised compounds.

MODULE A (Prof. A. Marrazzo) - (6 CFU)

1. Bibliography and notes provided in the course: http://http://studium.unict.it/dokeos/2016/courses/1003043C0/
2. D. J. A. Crommelin & R. D. Sindelar, BIOTECNOLOGIE FARMACEUTICHE, Zanichelli.
3. B. R. Glick, J. J. Pasternak, BIOTECNOLOGIA MOLECOLARE, Zanichelli.
4. M. L. Calabrò, Compendio di BIOTECNOLOGIE FARMACEUTICHE, EdiSES.
5. A. Maggi, BIOTECNOLOGIE FARMACOLOGICHE, MASSON.
6. E. Klegerman, M. J. Groves - Pharmaceutical Biotechnology - Interpharm Press, Inc.
7. J. M. Pezzuto, M. E. Johnson - Biotechnology and Pharmacy - Chapman & Hall, New York-London.
8. G. Walsh, D. Headon - Protein Biotechnology - J. Wiley & Sons.
9. K. Faber -BIOTRANSFORMATIONS IN ORGANIC CHEMISTRY.- Springer,
10. B. R. Glick, J. J. Pasternak - MOLECULAR BIOTECHNOLOGY, PRINCIPLES AND APPLICATIONS- Zanichelli .
11. L. Alberghina, E. Cernia - Biotecnologie e Bioindustria - Utet.
12. C. Quaglierini, M. Vannini - Chimica delle fermentazioni e laboratorio - Zanichelli

MODULE B (Prof.ssa L. Pasquinucci) - (3 CFU)

1. Bibliography and notes provided in the course.
2. Stuart Warren, Paul Wyatt - Organic synthesis -The Disconnection Approach, 2nd Edition - J. Wiley & Sons (2009).
3. Stuart Warren, Paul Wyatt - Workbook for Organic Synthesis The Disconnection Approach, 2nd Edition - J. Wiley & Sons (2009).
4. Laurie S. Starkey – Introduction to strategies for organic synthesis - J. Wiley & Sons (2012).