LABORATORY OF PHARMACEUTICAL BIOTECHNOLOGY - LABORATORY OF EXTRACTIVE AND SYNTHETIC PREPARATION OF DRUGS A - L

Module Laboratory of extractive and synthetic preparations of drugs

Provide the concepts and general strategies of retrosynthetic analysis for the resolution of complex synthetic problems through rational analysis; provide a basic experience in purification methods, identification and characterization of reaction and extraction products.

Acquired skills: theoretical and practical knowledge concerning the synthesis of organic compounds endowed with pharmacological activity. Theoretical and practical knowledge on purification methods and identification of the synthesized compounds.

• Frontal lessons 28 hours
• Laboratory practice 30 hours

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Class attendance is mandatory. The maximum limit of absences allowed is 30% of the total hours of lessons.

The final exam is written. Learning assessment may also be carried out on line, should the conditions require it.

Information for students with disabilities and / or SLD:
To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the Department, prof.ssa Teresa Musumeci.

To have passed and/or having a good knowledge of the following courses: General and Inorganic Chemistry, Organic Chemistry 1 and 2, Physical methods oforganic chemistry, Analytical Chemistry, Pharmaceutical and Toxicological Chemistry, Laboratory Drug Analysis, Physics, Informatics and Mathematics.

Class attendance is mandatory in accordance with the Institutional Regulations found at the following link: http://www.dsf.unict.it/corsi/lm-13_ctf/regolamento-didattico

• Drugs of extractive, synthetic and semi-synthetic origin.
• Design of a synthetic method: means and development of bibliographic research.
• Retrosynthetic analysis.
• Detailed analysis of the syntheses and reaction mechanisms involved in the preparation of compounds for therapeutic use and in the synthesis of molecules of biological origin: strategies and methods.
• Common equipments, instrumentations and laboratory methods.
• Translation of a synthetic plan into practical applications.
• Synthesis of some simple organic compounds.
• Synthesis of organic compounds with potential or known pharmacological activity.
• Application of different chromatographic methods and analytical and spectroscopic techniques for purification and identification of synthesized compounds

• Stuart Warren, Paul Wyatt - Organic synthesis -The Disconnection Approach, 1st and 2nd Edition - J. Wiley & Sons (1982/2009).
• Stuart Warren, Paul Wyatt - Workbook for Organic Synthesis The Disconnection Approach, 1st and 2nd Edition - J. Wiley & Sons (1982/2009).
• Experimental Organic Chemistry: A Miniscale & Microscale Approach, 6th Edition. John C. Gilbert, Stephen F. Martin. ISBN: 9781305080461
• A Small Scale Approach to Organic Laboratory Techniques, 4th Edition. Donald L. Pavia, George S. Kriz, Gary M. Lampman, Randall G. Engel. ISBN: 9781305253926.

• Examples of retrosynthetic analysis.
• Methodologies for the synthesis of substances of pharmacological interest.