FARMACOLOGIA E FARMACOTERAPIA

Academic Year 2024/2025 - Teacher: SANTINA CHIECHIO

Expected Learning Outcomes

The course in Pharmacology and Pharmacotherapy includes face-to-face lectures and it is aimed to provide students with the pharmacological bases of therapy and the pharmacological profiles of the most commonly used drugs.

At the end of the course the student will be able to:

1) describe the mechanism of action and therapeutic uses of the main drugs prescribed in therapy;

2) describe the pharmacokinetic and pharmacodynamic concepts that regulate the pharmacological profile of the most used drugs.

Course Structure

Face-to-face lectures

In case of mixed or remote mode, due to the pandemic situation, necessary changes can be introduced, in order to accomplish the planned program as reported in the syllabus.

Information for students with disabilities and/or SLD: In order to guarantee equal opportunities and in compliance with regulations in force, interested students can ask for a personal interview in order to plan any compensatory and/or dispensatory measures, based on the didactic objectives and specific needs. It is also possible to contact our Department CInAP referent, Prof. Santina Chiechio

Schedule: https://www.dsf.unict.it/courses/lm-13_ctf/lectures-schedule

Required Prerequisites

Basic knowledge of anatomy, physiology, and biochemistry.

Attendance of Lessons

Mandatory attendance according to the rules of the teaching regulations of the Degree Course in CTF, as indicated in the following link: http://www.dsf.unict.it/corsi/lm-13_ctf/regolamento-didattico

Detailed Course Content

GENERAL PHARMACOLOGY

Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination

Pharmacodynamics: Molecular Mechanisms of Drug Action

NEUROTRANSMISSION. THE AUTONOMIC AND SOMATIC MOTOR NERVOUS SYSTEMS

Muscarinic Receptor Agonists and Antagonists

Anticholinesterase Agents

Agents Acting at the Neuromuscular Junction and Autonomic Ganglia

Adrenergic Agonists and Antagonists

5-Hydroxytryptamine (Serotonin) and Dopamine

NEUROTANMISSION AND THE CENTRAL NERVOUS SYSTEM

Drug Therapy of Depression and Anxiety Disorders

Pharmacotherapy of Psychosis and Mania

Hypnotics and Sedatives

Opioids, Analgesia, and Pain Management

General Anesthetics and Therapeutic Gases

Local Anesthetics

Pharmacotherapy of the Epilepsies

Treatment of Parkinson Disease

MODULATION OF CARDIOVASCULAR FUNCTION

Regulation of Renal Function and Vascular Volume

The Renin-Angiotensin System

Pharmacotherapy of Hypertension

Pharmacotherapy of Congestive Heart Failure

Anti-Arrhythmic Drugs

Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

Drug Therapy for Hypercholesterolemia and Dyslipidemia

INFLAMMATION AND IMMUNOMODULATION

Histamine, Bradykinin, and Their Antagonists

Anti-Inflammatory, Antipyretic, and Analgesic Agents

Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus

Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease

GENERAL PRINCIPLES OF ANTIMICROBIAL THERAPY

GENERAL PRINCIPLES OF CANCER CHEMOTHERAPY

Textbook Information

1- B. G. Katzung Basic and Clinical Pharmacology. Latest edition.

2- Goodman and Gilman. The Pharmacological Basis of Therapeutics. Latest edition.

Course Planning

	Subjects	Text References
1	Definizioni di Farmacologia Generale, Farmacoterapia e loro finalità. Concetto di farmaco, medicamento, veleno.	2
2	FARMACOCINETICA. Principi generali del passaggio dei farmaci attraverso le membrane biologiche.	2
3	Assorbimento dei farmaci. Vie di somministrazione. Biodisponibilità	2
4	Distribuzione dei farmaci. Legame dei farmaci alle proteine plasmatiche.	2
5	Metabolismo dei farmaci. Meccanismi molecolari del metabolismo dei farmaci. Significato funzionale del metabolismo dei farmaci.	2
6	Eliminazione dei farmaci. Vie di eliminazione dei farmaci	2
7	Valutazione dei parametri di farmacocinetica. Emivita di un farmaco.	2
8	FARMACODINAMICA. Variabilità nella risposta ai farmaci. Effetti indesiderati dei farmaci.	1, 2
9	FARMACODINAMICA. Sedi e meccanismi d'azione dei farmaci	1, 2
10	Classificazione dei recettori e meccanismi di trasduzione del segnale.	1
11	Farmacologia dei canali ionici.	1
12	Interazione farmaco-recettore. Relazione dose-effetto. Farmaci agonisti, agonisti parziali, agonisti inversi e antagonisti. Potenza ed efficacia dei farmaci.	1
13	Neurotrasmissione catecolaminergica. Farmaci simpaticomimetici e simpaticolitici	1, 2, 3
14	Neurotrasmissione colinergica. Farmaci colinomimetici. Farmaci anticolinergici.	1, 2, 3
15	Neurotrasmissione GABAergica. Farmaci attivi sulla trasmissione GABAergica.	1, 2, 3
16	Neurotrasmissione serotoninergica.	1, 2, 3
17	Neurotrasmissione glutammatergica.	1, 2, 3
18	Farmcai del sistema nervoso centrale. Farmaci antipsicotici. Farmaci antidepressivi. Farmaci antimaniacali. Farmaci ansiolitii. Farmaci ipnotici e sedativi. Farmaci antiepilettici. Farmaci antiparkinsoniani	2
19	Analgesici oppioidi e non oppioidi. Terapia del dolore. Farmaci per la terapia dell’emicrania.	2
20	Anestetici generali. Anestetici locali	2
21	Autacoidi e mediatori dell’infiammazione	1, 2
22	Farmaci antistaminici	1
23	Farmaci antinfiammatori non steroidei	2
24	Farmaci Antinfiammatori steroidei	2
25	Farmaci immunomodulatori.	2
26	Farmaci attivi sull’apparato cardiovascolare. Farmaci antianginosi. Farmaci antiaritmici. Farmaci antipertensivi. Farmaci per il trattamento dell’insufficienza cardiaca.	2
27	Farmaci attivi sull’apparato urinario. Farmaci diuretici.	2
28	Farmaci attivi sull’apparato respiratorio.	2
29	Farmaci attivi sull’emopoiesi e sulla coagulazione.	2
30	Farmaci attivi sul metabolismo. Farmaci antidiabetici. Farmaci antidislipidemici.	2
31	Farmaci attivi sul sistema endocrino.	2
32	Farmaci attivi sul sistema digerente.	2
33	Principi generali di chemioterapia antibatterica e antivirale.	1, 2, 3
34	Principi generali di chemiotarapia antineoplastica	1, 2, 3

Learning Assessment

Learning Assessment Procedures

The examination is conducted through an oral test.

Schedule: https://www.dsf.unict.it/courses/lm-13_ctf/exams-calendar

Information for students with disabilities and/or learning disorders (DSA):

In order to ensure equal opportunities and compliance with current laws, interested students can request a personal interview to plan any compensatory and/or dispensatory measures based on their educational objectives and specific needs.

It is also possible to contact the CInAP (Center for Active and Participatory Integration - Services for Disabilities and/or DSA) faculty coordinator in our department, Professor Santina Chiechio.

Examples of frequently asked questions and / or exercises

Describe the processes of drug absorption, distribution, and elimination.

Describe drug metabolism.

Describe the mechanisms of drug-receptor interaction.

Describe the mechanism of action and therapeutic uses of beta-blocker drugs.

Drugs used in pain therapy.

Describe the mechanism of action of non-steroidal anti-inflammatory drugs.

Describe the mechanism of action and therapeutic uses of beta-lactam antibiotics.

Pharmacological therapy for herpes infections.

Describe the mechanism of action of monoclonal antibodies used in anticancer therapy.

Degree Course in

Pharmaceutical Chemistry and Technology