IDENTIFICATION OF DRUGS M - Z
Academic Year 2016/2017 - 3° YearCredit Value: 6
Scientific field: CHIM/08 - Pharmaceutical chemistry
Taught classes: 28 hours
Term / Semester: 1°
Learning Objectives
At the end of the course, which also consists of laboratory exercises in a single place, the student acquires the knowledge and practice for the identification of compounds of pharmaceutical interest, mainly with organic structure, by means of specific chemical assays and instrumental analytical techniques. The student will be able to employ the methods reported in the Italian Official Pharmacopoeia and European Pharmacopoeia.
Detailed Course Content
Preliminary testing: Tasting notes, essays Combustion, organic elemental analysis, quantitative elemental analysis, examination of the chemical, solubility assays
Physical Constants: Melting Point, Boiling Point, Density, Refractive index,
Polarimetry (specific rotatory power: determination of specific rotatory power; scheme of the instrument, determination of optical purity).
Recognition of Functional Groups:
Carboxylic acids, hydroxy acids, phenols, alcohols, aldehydes and ketones, esters, lactones, anhydrides, ethers, halogen derivatives, amines, amides, amino acids, nitro compounds, hydrocarbons.
IR spectroscopy
Spectroscopy molecular absorption: General
Classical model, quantum model, frequency group, polyatomic molecules
Interpretation of the IR spectrum
Instrumentation
Sample preparation and recording of the spectrum
applications
MASS spectrometry
the instrumentation
Ionization techniques
Analysis of fragmentation in EI
analyzers
Tandem mass spectrometry
Applications of mass spectrometry
Monographs: benzoic acid, ascorbic acid, tartaric acid, methyl and propyl p-hydroxybenzoate, acetylsalicylic acid, benzocaine, adrenaline, saccharin, paracetamol.
DEFINITION OF ANALYTICAL PROFILES OF THE FOLLOWING CLASSES OF DRUGS
-Sulfonamides: a) Antibiotics (sulfonamides) b) Antidiabetic agents (sulphonylureas) c) Diuretics
-Carbohydrates: glucose, fructose, lactose, sucrose
-Benzodiazepine
-Steroids
-Beta-lactam antibiotics
Textbook Information
- CAVRINI-ANDRISANO "Analisi Farmaceutica" vecchia (2004) e nuova (2009) edizione
- SAVELLI-BRUNO “Analisi chimico farmaceutica” Piccin (ristampa 2005);
- CARTA-MAMOLO-NOVELLI-PIRAS “Analisi Farmaceutica Qualitativa”
EdiSES (2011)