TECNOLOGIA FARMACEUTICA - LABORATORIO GALENICO A - L

Learning Objectives

• Pharmaceutical Technology and Laboratory of Pharmaceutical Technology

  The course aims to deepen technological, biopharmaceutical and formulative aspects of both traditional and innovative pharmaceutical formulation, now available to the medical therapy.

  In particular, it will be pay great attention to the fields of interest concerning the preparation of both magistral and officinal galenic medicines, and controls assay provided by the NBP (Guidelines of good preparation) and the Pharmacopoeia in force.

• Laboratory of Pharmaceutical Galenic

  The main objective of the course is to provide the basic knowledge for the shipment of a galenic recipe with particular attention to: the responsibility of the pharmacist, filling out the worksheet and label, pricing, preparation of the most common pharmaceutical galenic forms, controls on final preparations.

Detailed Course Content

• Pharmaceutical Technology and Laboratory of Pharmaceutical Technology

  PART 1 (5 CFU)

  SECTION 1A

  Stability and biopharmaceutic (1 CFU)

  Stability and stabilization of medicinal

  Rules for the proper preservation, preservatives (antimicrobials and antioxidants), general characteristics of the containers for medicines.

  Concepts of biopharmaceutic

  Influence of selected formulation on the bioavailability and activity of drugs. Preformulation.

  Conventional pharmaceutical preparations (4 CFU)

  Water for pharmaceutical use; aqueous and hydroalcoholic solutions in pharmacy; suspensions, emulsions, surfactants.

  Liquid preparations for oral use (syrups, powders and granules for syrups, solutions, emulsions, suspensions, powders for solutions or suspensions, drops, powders drops).

  Ophthalmic preparations (eye drops, eye baths, powders for eye drops and eye baths, ophthalmic semisolid preparations, ocular inserts).

  Parenteral preparations: classification, routes of administration, requirements, chemico-physical and biological assays.

  Pressurized pharmaceutical forms.

  The solid dosage forms: classification, routes of administration, requirements, chemico-physical and biological assays of powders, granules, tablets and capsules. Coating of tablets: pelleting, filming, enteric coatings.

  Semi-solid and topical pharmaceutical forms.

  Semi-solid preparations for cutaneous application (ointments, creams, gels, pastes, poultices, medicated plasters).

  Rectal preparations (suppositories).

  Vaginal preparations (ovules)

  Nasal and headsets preparations.

  PART 2 (4 CFU)

  Unconventional and innovative pharmaceutical preparations (3 CFU)

  Pharmaceutical preparations to achieve modified release

  Oral forms, trans-mucosal, ophthalmic, subcutaneous grafting plants, transdermal systems.

  Drug Delivery System (DDS) for drug release

  Vesicular systems (liposomes, niosomes). Micro and nanoparticulate polymeric systems. Lipidic nanoparticulate systems (SLN and NLC).

  Chemical approach for the improvement of drug physico-chemical properties

  Prodrugs and polymeric prodrugs, drug-polymer conjugates, molecular inclusion systems (cyclodextrins).

  Complementary fields of pharmaceutical interest (1 CFU)

  Traditional and modern herbal preparations.

  Outline of the theoretical fundamentals and the technology of homeopathic preparations.

  LABORATORY OF PHARMACEUTICAL GALENIC (5 CFU)

  Fundamental pharmaceutical operations

  Basic operations in pharmaceutical technology

  Solution, filtration, concentration, drying, freeze drying, sterilization, grinding and pulverizing, granulating.

  Definition and development of medicines. Galenic and industrial medicines. Official Italian Pharmacopoeia (F.U.I.) XII edition. European Pharmacopoeia VIII Edition. Guidelines of good preparation (N.B.P.).

  The magistral preparation (exercises to individual place)

  Exam concerning the delivery of prescriptions. Incompatibility. Rate National of Medicines. Techniques for the preparation of the most common galenic pharmaceutical forms.

  Lessons will be supplemented by group seminars.

• Laboratory of Pharmaceutical Galenic

  Fundamental operations in pharmaceutical technology: solution, filtration, concentration, drying, freeze drying, sterilizing, grinding and pulverizing, granulating. Medicine and pharmaceutics industry, Galenic, F.U. XII Edition, European Pharmacopoeia 8 Edition. Good preparation standards. The preparation of galenic pharmaceutical forms (individual place exercises). Examination and delivery of prescriptions. Incompatibility. National Medicines rate. Techniques for the preparation of the most common galenic pharmaceutical forms. Seminars on specialized topics will be organized during the course of the year.

Textbook Information

• Pharmaceutical Technology and Laboratory of Pharmaceutical Technology

  SUGGESTED BOOKS FOR STUDY
  1. P. Colombo et al. - PRINCIPI DI TECNOLOGIA FARMACEUTICA – seconda
  edizione – Casa Editrice Ambrosiana, 2015.
  2. M. Amorosa – PRINCIPI DI TECNICA FARMACEUTICA - Libr. Univ. Tinarelli,
  Bologna 1998.
  3. M.E. Aulton – TECNOLOGIE FARMACEUTICHE Progettazione e allestimento dei
  medicinali. Edizioni EDRA, 2013.
  4. Medicamenta VII Ed. (1° vol.) - Cooperativa Farmaceutica, Milano.
  5. Enrico Ragazzi “Galenica Pratica” Formulazione e Tecnologia. – Ed. 2006 – Libreria
  Internazionale Cortina Padova.
  6. Franco Bettiol - Manuale delle preparazioni galeniche Tecniche Nuove Ed. 2003.

  Updates are available on the site Lecturer: https://sites.google.com/site/puglisipharmtech/home/materiale-didattico/tecnologia-farmaceutica

  
  BOOKS TO BE CONSULTED
  7. F.U.I. XII Ed. and supplements.
  8. Farmacopea Europea VIII Ed. and supplements.
  9. T.A. Florence & D. Attwood – Le basi chimico-fisiche della tecnologia farmaceutica -
  McMillan Press 2002.
  10. Martin - Physical Pharmacy - Lea & Febiger, Philadelphia, London.
  11. Remington’s Pharmaceutical Sciences, 19th Ed.
  12. Livingstone – Pharmaceutics. The science of dosage form design- Ed. ME Aulton.
  13. Teacher's online slides.

• Laboratory of Pharmaceutical Galenic

  1. P. Colombo et al. - PRINCIPI DI TECNOLOGIA FARMACEUTICA – seconda edizione – Casa Editrice Ambrosiana, 2015.

  2. M. Amorosa – PRINCIPI DI TECNICA FARMACEUTICA - Libr. Univ. Tinarelli, Bologna 1998.

  3. M.E. Aulton – TECNOLOGIE FARMACEUTICHE Progettazione e allestimento dei medicinali. Edizioni EDRA, 2013.

  4. Medicamenta VII Ed. (1° vol.) - Cooperativa Farmaceutica, Milano.

  5. Enrico Ragazzi “Galenica Pratica” Formulazione e Tecnologia. – Ed. 2006 – Libreria Internazionale Cortina Padova.

  6. Franco Bettiol - Manuale delle preparazioni galeniche Tecniche Nuove Ed. 2003.

  7. Farmacopea Ufficiale Italiana XII Edizione.