TECNOLOGIA FARMACEUTICA 2 - SISTEMI DI RILASCIO AVANZATO DEI FARMACIModule SISTEMI DI RILASCIO AVANZATO DEI FARMACI
Academic Year 2024/2025 - Teacher: LUCIA MONTENEGROExpected Learning Outcomes
The aim of this course is to provide the student with knowledge and expertise about the strategies exploited in the field of drug-modified release and targeting. In particular, the course focuses on the fundamental concepts of drug controlled delivery and targeting illustrating the technological properties and the pharmaceutical applications of the main controlled drug delivery systems.
Course Structure
Frontal lessons (4 CFU) and laboratory activities in groups (1 CFU). Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Information for students with disabilities and / or SLD
To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the Department of Drug and Health Sciences.
Required Prerequisites
Basic knowledge of organic chemistry and pharmaceutical technology.
Attendance of Lessons
Attendance is mandatory and is gained attending at least 70% of lessons.
Detailed Course Content
Controlled drug delivery systems: classification. Active and passive drug targeting. Fundamentals of controlled drug delivery systems: reservoir systems, osmotic systems, matrix systems, ion exchange systems.
Vesicular controlled delivery systems. Liposomes: advantages and limits: Classification, main methods of preparation and physico-chemical and technological characterization. Examples of applications in the pharmaceutical field. Vesicular controlled delivery systems derived from liposomes: ethosomes, transfersomes, niosomes. Technological properties and uses in the pharmaceutical field.
Microparticles
as controlled delivery systems: advantages and limits. Preparation and
characterization methods. Applications the pharmaceutical field.
Nanoparticles as controlled delivery systems: polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers. Advantages and limits. Methods of preparation and physico-chemical/technological characterization. Applications in the pharmaceutical field.
Metal nanoparticles as delivery systems: definition and classification. Main methods of preparation and characterization. Applications in the pharmaceutical field.
Chemically controlled delivery systems: prodrugs. Advantages and limits. Properties and uses in the pharmaceutical field.
Molecular inclusion complexes as delivery systems: cyclodextrins. Definition and classification. Preparation methods of cyclodextrin-drug inclusion complexes. Instrumental analyses to characterize inclusion complexes. Uses in the pharmaceutical field.
Transdermal delivery systems: advantages and limits. Technological properties and applications in the pharmaceutical field.
Drug delivery systems in gene therapy: fundamentals and goals. DNA and the oligonucleotide delivery: viral and synthetic carriers (liposomes, cationic polymers and lipopolyplexes).
Laboratory activities in groups: liposome prepration and purification by dialysis; incorporation of purified liposomes into suitable formulations and evaluation of active compound release from the vehicle.
Textbook Information
1. COLOMBO P., CATELLANI P.L., GAZZANIGA A., MENEGATTI E., VIDALE E.; Principi di tecnologie Farmaceutiche; Casa Ed. Ambrosiana, Ultima Edizione.
2. FLORENCE A.T. AND ATTWOOD D.; Le basi chimico-fisiche della Tecnologia Farmaceutica; Edises, Ultima Edizione.
3. AULTON M.E. AND TAYLOR K.M. Tecnologie farmaceutiche. Progettazione e allestimento dei medicinali; Edra, Ultima Edizione1.1
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | 1,2,3 | Controlled drug delivery systems |
| 2 | 1,3 | Vesicular drug delivery systems |
| 3 | 1 | Microparticles as controlled drug delivery systems |
| 4 | 3 | Nanoparticles as controlled drug delivery systems |
| 5 | 3 | Cyclodextrins as drug delivery systems |
| 6 | 1 | Transdermal drug delivery systems |
Learning Assessment
Learning Assessment Procedures
Learning assessment is performed in the form of written test consisting of 5 open questions. The exam lasts two hours.
Learning assessment may also be carried out on line, should the conditions require it.
Examples of frequently asked questions and / or exercises
1. Preparation methods used for liposomes
2. Advantages and limits of drug transdermal administration
3. Technological properties of solid lipid nanoparticles
4. Use of liposomes in gene therapy
5. Microparticles as drug carriers